There are multiple causes of orthopedic disease. Often, trauma to the skeletons leads to orthopedic conditions that cause damage to the soft tissues or bruising and fractures. Infections that derive from microorganisms can even lead to a requirement of orthopedic care. Cancers and immune disorders often have side effects like weakness of the bones, sore joints, or fractures that may result in orthopedic disease. Finally, age-related conditions such as arthritis may end up in need of orthopedic surgery.